A Practical Synthesis of threo-3-Amino-2-hydroxycarboxylic Acids

Article abstract of DOI:10.1246/bcsj.65.360

An expeditious synthesis of (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid (2) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutyric acid (4), the key components of the renin inhibitor (1) and bestatin (3), respectively, have been accomplished by featuring hi