ASYMMETRIC MICHAEL ADDITION OF CHIRAL IMINES TO PHENYLVINYLSULFONE: PREPARATION OF KEY CHIRAL BUILDING BLOCKS FOR THE SYNTHESIS OF ASPIDOSPERMA AND HUNTERIA ALKALOIDS

Article abstract of DOI:10.1016/S0957-4166(00)82358-7

Addition of chiral imine 8 to phenylvinylsulfone 9 led, after hydrolytic work-up to adduct 11 (91percent stereoselectivity).This derivative has been converted into target cyclopentanones 14 and 16.