A Water-Soluble Spin Probe Newly Developed for Liposomale Studies

Article abstract of DOI:10.1246/bcsj.65.1041

A water-soluble spin probe, disodium 4-<(4,8-sulfonatooxy-2-naphthyl)thioureylene>-2,2,6,6-tetramethyl-1-piperidinyloxyl (TEMPO-T) was newly synthesized and characterized comparing with several defferent TEMPO derivatives from the view point of a possibility of utilization in the liposomal studies.Of TEMPO derivatives studied, TEMPO-T was the best probe because of the high water solubility, the less lipophilicity, the less leakiness from liposome, and the reliable stability to both temperature and pH changes.