Ir(I)-catalyzed enantioselective secondary sp3 C-H bond activation of 2-(alkylamino)pyridines with alkenes

DOI: 10.1021/ol201907w

Source and publish data:

Organic Letters p. 4692 - 4695 (2011)

Update date:2022-08-03

Topics:

Authors:

Pan, Shiguang

Endo, Kohei

Shibata, Takanori

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Article abstract of DOI:10.1021/ol201907w

A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation initiated by secondary sp³ C-H bond cleavage adjacent to a nitrogen atom. The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.

Full text of DOI:10.1021/ol201907w

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