Tetrahedron p. 3627 - 3638 (1994)
Update date:2022-08-03
Paleo, M. Rita
Dominguez, Domingo
Castedo, Luis
The photocyclization of N-(2-arylethyl)phthalimides to 4-aryl-2-benzazepine-1,5-diones is described.We found that the presence of electron donating substituents on the aryl ring (as in 10a and b) is necessary for the cyclization process to occur.The procedure also allowed synthesis of 2-benzazepinediones with a carboxylate group at C3 (11c and d) which were obtained as 1:1 mixture of diastereoisomers.The results of irradiating phthalimides 12, which bear an oxygenated substituent at the benzylic position, depended on the nature of the substituent.Attempts to photocyclize N-(indan-2-yl)phthalimides 16 and the electron-rich phthalimide 23 failed.
View Morewebsite:http://www.lidepharma.com
Contact:+86-25-58409506
Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.
Chengdu Push Bio-technology Co., Ltd
Contact:86-28-85370565
Address:No.8 Wuke West Second Road, Wuhou
Hubei Lansun Biochemical Pharmaceutical Co., Ltd
Contact:714-6395977
Address:No. 81 Pengcheng Avenue, economic and technological development zone, Huangshi City, Hubei Province,China
Contact:+86-27-87204219, +86-27-87215023
Address:2402, HuiGu Space-time Building, 8 Forest Road, East Lake Hi-Tech Development Zone
Tianjin Pharmacn Medical Technology Co.,Ltd.
Contact:86-22-60122566ext.866(English),23359620
Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Doi:10.1021/la203683u
(2012)Doi:10.1016/j.jfluchem.2019.109367
(2019)Doi:10.1002/jhet.743
(2011)Doi:10.1016/j.tetlet.2015.11.016
(2015)Doi:10.1016/j.bmc.2011.10.010
(2011)Doi:10.1016/j.bmc.2011.10.054
(2011)