Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine

Article abstract of DOI:10.1021/jm00065a007

Alicyclic and heteroalicyclic derivatives of 9-deazaguanine (2-amino-1,5- dihydro-4H-pyrrolo[3,2-d][pyrimidin-4-one) are, with one exception, potent inhibitors of purine nucleoside phosphorylase (PNP) equaling the corresponding 9-arylmethyl derivatives pr