Tetrahedron p. 226 - 237 (2012)
Update date:2022-08-04
Topics:
Kolla, Srinivasa Rao
Lee, Yong Rok
One-pot three-component reactions of arylaldehyde or salicylaldehyde with malononitrile (or ethylcyanoacetate) and triethyl phosphite are carried out in the presence of ethylenediamine diacetate (EDDA) as a catalyst for the synthesis of biologically interesting β-phosphono malonates and 2-amino-4H-chromen- 4-ylphosphonate derivatives. The value of this method lies in its mild reaction catalyst and conditions, good yields, and ease of handling.
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