3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 8. Side Chain Ether Analogues of Lovastatin

DOI: 10.1021/jm00112a024

Source and publish data:

Journal of Medicinal Chemistry p. 2474 - 2477 (1991)

Update date:2022-08-05

Topics:

Authors:

Lee, T.-J.

Holtz, W. J.

Smith, R. L.

Alberts, A. W.

Gilfillan, J. L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00112a024

A general route for preparing side chain ether analogues of lovastatin is presented.These analogues proved to be weaker inhibitors of HMG-CoA reductase than the corresponding side chain ester analogues.Interestingly, inhibitory potency was enhanced marked

Full text of DOI:10.1021/jm00112a024

Products guided by the article

Product name:4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-<(tetrahydropyran-2-yl)oxy>-3,4,5,6-tetrahydro-2H-pyran

Cas No:135413-68-2

R&D Labs maybe for 135413-68-2

Hangzhou yi lu biont technology Co., LTD

Contact:+86-571-88152630

Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
Yingkou Sanzheng Organic Chemical Co. Ltd.

Contact:+86-417-3638818

Address:25 Gengxinli Village, Daqing Road, Yingkou, Liaoning, China
taizhou creating bio-pharm co.,ltd.

Contact:+86- 576- 88827176

Address:715 room ,unit A.junyue Building,Jiaojiang,Taizhou,Zhejiang,China
Nanjing Norris Pharm Technology Co., Ltd.

Contact:+86-13901585132

Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China
Suzhou HeChuang Chemical Co.,Ltd.

Contact:+86-512-88800520

Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park

Relevant to this article

Remarkable stereoselectivity in intramolecular Borono-Mannich reactions: Synthesis of conduramines

Doi:10.1021/ol203162s
(2012)
Reaction of methyl 3-[(dimethylamino)methylidene]-6-fluoro-4-oxo -3,4-dihydrochroman-2-carboxylate with primary and secondary amines

Doi:10.1007/s10593-011-0859-0
(2011)
Annelation Reactions of 4-Alkynylcyclobutenones. Formation of Methylenebenzofurans

Doi:10.1021/jo00021a026
(1991)
Preparation of (Z)-1-fluoro-1-alkenyl carboxylates, carbonates and carbamates through chromium mediated transformation of dibromofluoromethylcarbinyl esters and the reactivity as double acyl group donors

Doi:10.1016/j.jfluchem.2011.07.022
(2012)
Synthesis and phase behavior of branched esters derived from cyclohexylbenzoic acid

Doi:10.1134/S1070363211110119
(2011)
Discrete Benzotriazole-Copper(II) Complexes in Chelated and Non-Chelated Coordination Modes: Structural Analysis and Catalytic Application in Click and A³ Coupling Reactions

Doi:10.1002/ejic.202100103
(2021)

Article Doi