3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 8. Side Chain Ether Analogues of Lovastatin

DOI: 10.1021/jm00112a024

Source and publish data:

Journal of Medicinal Chemistry p. 2474 - 2477 (1991)

Update date:2022-08-05

Topics:

Authors:

Lee, T.-J.

Holtz, W. J.

Smith, R. L.

Alberts, A. W.

Gilfillan, J. L.

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Article abstract of DOI:10.1021/jm00112a024

A general route for preparing side chain ether analogues of lovastatin is presented.These analogues proved to be weaker inhibitors of HMG-CoA reductase than the corresponding side chain ester analogues.Interestingly, inhibitory potency was enhanced marked

Full text of DOI:10.1021/jm00112a024

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