
Tetrahedron Letters p. 2395 - 2398 (1991)
Update date:2022-08-05
Topics:
Tomioka, Kiyoshi
Kanai, Motomu
Koga, Kenji
Total synthesis of dolastatin 10 (1) was completed by developing an efficient synthesis of two key amino acid components, Dil (6) and Dap (11), and subsequent stepwise coupling of five amino acid components from C-terminal Doe.
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