Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors

Article abstract of DOI:10.1016/j.tetlet.2011.12.049

A new C-glucosylated spiro-sulfamide has been prepared and evaluated toward glycogen phosphorylase inhibition. The synthesis was carried out successfully by nucleophilic displacement of 1-O-tosyl or 1-deoxy-1-iodo-α-d-gluco- hept-2-ulopyranose tetra-O-benzylated derivative using aryl amines, followed by the formation of the corresponding cyclic sulfamide.