Synthetic Studies on the Compounds Related to Neocarzinostatin Chromophore. 2. Synthesis of the Open-Chain (E)- and (Z)-Dienediyne Systems and Its Application to the Synthesis of an Strain-released Cyclic Analogue

Article abstract of DOI:10.1016/S0040-4020(01)92247-1

The "double coupling " reaction of the (E)- and (Z)-dienol ditriflates (5 and 6) with various propargyl alcohols was found to give the (E)- and (Z)-dienediyne diols, the open-chain analogues of neocarzinostatin chromophore, stereospecifically.Those (E)- a