Tetrahedron Letters p. 891 - 893 (2002)
Update date:2022-08-03
Topics:
Eriksson, Johan
Johansson, Martin
Sterner, Olov
Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerases, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields.
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Doi:10.1016/S0040-4039(00)95183-9
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(2009)Doi:10.1016/j.tetlet.2010.01.027
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(2009)Doi:10.1055/s-0040-1707400
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