EFFICIENT ROUTE TO THE SYNTHESIS OF C-2, C-3 SUBSTITUTED 4-PIPERIDONES

Article abstract of DOI:10.1016/S0040-4039(00)79755-3

1-Carbobenzoxy-3-carbomethoxy-5,6-dihydro-4-pyridone (1) has proven to be exceptionally receptive in the conjugate addition of organocuprates to give C-2 substituted piperidones having the C-3 position activated toward alkylation.Enone 1 was used as the k