Regioselective Synthesis of Δ6-, Δ7-, and Δ8-14α-Cyanosterol Derivatives: Versatile Precursors to 14α-Demethylase Inhibitors

DOI: 10.1021/jo00038a024

Source and publish data:

Journal of Organic Chemistry p. 3347 - 3353 (1992)

Update date:2022-09-26

Topics:

Authors:

Gallagher, Timothy F.

Adams, Jerry L.

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Article abstract of DOI:10.1021/jo00038a024

The efficient preparation of 3β-(benzoyloxy)-4,4-dimethyl-5α-cholest-8(14)-en-7-one (4a) and 3β-(benzyloxy)-5α-ergosta-8(14),22-dien-7-one (4b) and their conversion to Δ⁶-, Δ⁷- or Δ⁸-14α-functionalized sterols is reported.

Full text of DOI:10.1021/jo00038a024

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