Asymmetric Synthesis of Trisubstituted gem-Difluorocyclohexanes by Intramolecular Trapping of Difluoroalkyl Radicals.

Article abstract of DOI:10.1016/S0957-4166(00)82161-8

gem-Difluorocyclohexanols 8 bearing a methyl and a p-tolyl-sulphinyl substituent have been synthesized in optically pure form by intramolecular trapping of difluoroalkyl radicals on terminal double bonds.The radical intermediates have been generated by th