Asymmetric synthesis of 3′-carbomethoxymethyl 3′-deoxythymidine via radical cyclization

DOI: 10.1016/0040-4039(91)80808-J

Source and publish data:

Tetrahedron Letters p. 3469 - 3472 (1991)

Update date:2022-08-03

Topics:

Authors:

Lavallee, Jean-Francois

Just, George

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Article abstract of DOI:10.1016/0040-4039(91)80808-J

An efficient asymmetric synthesis of 3′-C-carbomethoxymethyl- 3′-deoxythymidine 2, using a highly stereocontrolled radical cyclization from bromoacetai 7 to furanose 8, followed by a dimethylboron bromide mediated nucleoside formation, is described. A 96:

Full text of DOI:10.1016/0040-4039(91)80808-J

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