Microwave-assisted synthesis of the (E)-α-methylalkenoate framework from multifunctionalized allylic phosphonium salts

Article abstract of DOI:10.1002/hc.21001

A convenient and general microwave-assisted method for the synthesis of stereochemically defined α-methylalkenoic acids and esters from allylic phosphonium salts in a basic aqueous medium is described. A selective preparation of acids or esters was dependent on the base (NaOH or NaHCO ₃) employed in the reaction and could be achieved with good to excellent yields under mild conditions in the absence of hydrides and reducing agents.