DOI: 10.1039/D0CC04831C
ChemComm
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In summary, we have demonstrated an efficient protocol for
the t-BuOK mediated cascade amidiation/N-alkylation of
amines by alcohols. Importantly, the reaction employs nitriles
as an inexpensive and benign water acceptor. Furthermore,
this transformation is very practical, and a series of functional
groups could be tolerated. As such, it represents a novel and
simple method to access the different substituted monoamino,
diamino compounds, 15N labeled amine molecule and could
scaled up to 1 mol scale. Further studies aimed at gaining a
50
55
5
3
10 detailed mechanistic understanding of this N-alkylation and
the application of base as the efficiently mediator in other
transformations are currently in progress in our laboratory.
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Figure 1 Distribution along with the reaction time.
15 Conflicts of interest
80
There are no conflicts of interest to declare.
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Acknowledgements
85
This research was supported by the National Natural
Science Foundation of China (No. 21571143), the Shandong
20 Provincial Natural Science Foundation of China (Nos.
ZR2017MB029, ZR2017BB060), the Qingdao Science
and Technology Foundation (18-2-2-49-jch) for financial
support.
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