Advanced Synthesis and Catalysis p. 1897 - 1902 (2016)
Update date:2022-08-04
Topics: Synthesis Transition metal Michael addition Experimental
Teng, Qing-Hu
Xu, Yan-Li
Liang, Ying
Wang, Heng-Shan
Wang, Ying-Chun
Pan, Ying-Ming
A transition metal-free and efficient method for the synthesis of 3-alkynylpyrrole-2-carboxylates from diynones and glycine esters or 2-aminoacetophenone hydrochloride has been developed. This transformation provides a large range of substituted pyrroles in good to excellent yields with the elimination of water as the only by-product. The detailed mechanistic studies elucidated that this transformation involves a Michael addition/intramolecular cyclodehydration process. (Figure presented.) .
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