Chemoenzymatic synthesis of both enantiomers of baclofen

DOI: 10.1016/S0040-4039(00)92140-3

Source and publish data:

Tetrahedron Letters p. 4249 - 4250 (1991)

Update date:2022-07-31

Topics:

Authors:

Chenevert, Robert

Desjardins, Michel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)92140-3

Both enantiomers of baclofen have been synthesized in five steps from 4-chlorocinnamic acid. The key step is the highly stereoselective enzymatic hydrolysis of dimethyl 3-(4-chlorophenyl)glutarate by chymotrypsin.

Full text of DOI:10.1016/S0040-4039(00)92140-3

Products guided by the article

Product name:dimethyl 3-(p-chlorophenyl)glutarate

Cas No:137310-15-7

R&D Labs maybe for 137310-15-7

SHANGHAI ARCADIA BIOTECHNOLOGY LTD.

Contact:+86-21-61353236

Address:SUITE 901, BUILDING WENSLI, 1378 LU JIA BANG RD, SHANGAHI 200011, P.R.CHINA
Hubei Danao Pharmaceutical Co.,Ltd.

website:http://www.danaopharm.com

Contact:+86-719-5251167

Address:Fandan Road,Danjiangkou,Hubei
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
XZL BIO-TECHNOLOGY CO., LTD.

Contact:0086 533 2282832

Address:Zibo，Shandong
Shanghai Surseechem Co.,Ltd.

Contact:+86-21-61318535

Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai

Relevant to this article

Aminotroponiminato hafnium and zirconium complexes: Synthesis and ethylene/1-octene copolymerization study

Doi:10.1021/om200362v
(2011)
Synthesis of 2-azido-1,3-thiazoles as 1,2,3-triazole precursors

Doi:10.1080/00397910902981274
(2010)
A FACILE METHOD FOR THE SYNTHESIS OF β-CHLOROALKYL SULFIDES USING DIMETHYL SULFOXIDE ACTIVATED BY PHENYL DICHLOROPHOSPHATE OR PHOSPHORUS OXYCHLORIDE

Doi:10.1016/S0040-4039(00)80788-1
(1988)
1H NMR Spectroscopy of Cycloadducts of 1,5- and 1,6-Diazaphenanthrene Phenacylides

Doi:10.1002/mrc.1260291018
(1991)
Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes

Doi:10.1021/ja910090v
(2010)
Cascade synthesis of 2-Amino-5-(4-methoxyphenyl)-4-phenyl-1,3-thiazole by Reaction of 4-Chloro-N-[2,2-dichloro-1-(4-methoxyphenyl)-2-phenylethyl] benzenesulfonamide with Thiourea

Doi:10.1134/S1070428011040178
(2011)

Article Doi