Chemoenzymatic synthesis of both enantiomers of baclofen

DOI: 10.1016/S0040-4039(00)92140-3

Source and publish data:

Tetrahedron Letters p. 4249 - 4250 (1991)

Update date:2022-07-31

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Authors:

Chenevert, Robert

Desjardins, Michel

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Article abstract of DOI:10.1016/S0040-4039(00)92140-3

Both enantiomers of baclofen have been synthesized in five steps from 4-chlorocinnamic acid. The key step is the highly stereoselective enzymatic hydrolysis of dimethyl 3-(4-chlorophenyl)glutarate by chymotrypsin.

Full text of DOI:10.1016/S0040-4039(00)92140-3

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