Synthesis and Antibacterial Activities of C-21 Functionalized Derivatives of (9R)-9-Amino-9-deoxoerythromycins A and B

Article abstract of DOI:10.1021/jm00116a008

Selective protection of (9R)-9-amino-9-deoxoerythromycin A allowed for elimination of the 12-hydroxyl group to afford a versalite 12,21-olefin intermediate.Further modifications of the intermediate led to the syntheses of (9R)-9-deoxo-9-(N,N-dimethylamino