Easy Direct Stereo- and Regioselective Formation of β-Hydroxy Nitriles by Reaction of 1,2-Epoxides with Potassium Cyanide in the Presence of Metal Salts

DOI: 10.1016/S0040-4039(00)92305-0

Source and publish data:

Tetrahedron Letters p. 4775 - 4778 (1991)

Update date:2022-07-30

Topics:

Authors:

Chini, Marco

Crotti, Paolo

Favero, Lucilla

Macchia, Franco

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Article abstract of DOI:10.1016/S0040-4039(00)92305-0

A simple efficient, anti stereoselective, and highly regioselective method for the synthesis of β-hydroxy nitriles by the direct opening of 1,2-epoxides with KCN in acetonitrile, in the presence of metal salts, is described.This new method appears to be competitive with the other methods previously reported. Key words: β-hydroxy nitriles; epoxide opening reactions; regioselectivity; catalysts.

Full text of DOI:10.1016/S0040-4039(00)92305-0

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