Tetrahedron Letters p. 4775 - 4778 (1991)
Update date:2022-07-30
Topics:
Chini, Marco
Crotti, Paolo
Favero, Lucilla
Macchia, Franco
A simple efficient, anti stereoselective, and highly regioselective method for the synthesis of β-hydroxy nitriles by the direct opening of 1,2-epoxides with KCN in acetonitrile, in the presence of metal salts, is described.This new method appears to be competitive with the other methods previously reported. Key words: β-hydroxy nitriles; epoxide opening reactions; regioselectivity; catalysts.
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