Easy Direct Stereo- and Regioselective Formation of β-Hydroxy Nitriles by Reaction of 1,2-Epoxides with Potassium Cyanide in the Presence of Metal Salts

DOI: 10.1016/S0040-4039(00)92305-0

Source and publish data:

Tetrahedron Letters p. 4775 - 4778 (1991)

Update date:2022-07-30

Topics:

Authors:

Chini, Marco

Crotti, Paolo

Favero, Lucilla

Macchia, Franco

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)92305-0

A simple efficient, anti stereoselective, and highly regioselective method for the synthesis of β-hydroxy nitriles by the direct opening of 1,2-epoxides with KCN in acetonitrile, in the presence of metal salts, is described.This new method appears to be competitive with the other methods previously reported. Key words: β-hydroxy nitriles; epoxide opening reactions; regioselectivity; catalysts.

Full text of DOI:10.1016/S0040-4039(00)92305-0

Products guided by the article

Product name:(1R,2S)-2-Hydroxy-2-phenyl-cyclohexanecarbonitrile

Cas No:137422-10-7

R&D Labs maybe for 137422-10-7

Shijiazhuang Yunxuan Im&Export Co.,Ltd.

Contact:+86-311-83037514

Address:No.6 Hongbin Road
CHENGDU CHENLV HERB CO.,LTD

Contact:+86-28-88523492

Address:714rooms of Time Square, Pujiang County
Ningbo J&S Botanics Inc.

Contact:86-574-26865651

Address:529 YuanBaoShan Road, Beilun District
Huaian Double Win Chemicals Co.,Ltd.

Contact:+86-13511538872

Address:Blk 43,Greenland Century Town,Huaian District, Huaian City,Jiangsu Province,China
Chongqing maohuan Chemicals Co., Ltd

website:http://www.bschem.com

Contact:+86 13996103726

Address:Chongqing Nan'an District Tu Town

Relevant to this article

An unexpected synthesis of dihydrophenazines en route to benzimidazolium salts

Doi:10.1002/adsc.201100890
(2012)
Doi:10.1021/ja01157a109
(1950)
4-Methoxy-1,3-thiazole based donor-acceptor dyes: Characterization, X-ray structure, DFT calculations and test as sensitizers for DSSC

Doi:10.1016/j.dyepig.2012.02.014
(2012)
Synthesis and spectrum of biological activities of novel N-arylcinnamamides

Doi:10.3390/ijms19082318
(2018)
Synthesis of new C₂-symmetrical bis(hydroxycamphorsulfonamide) ligands and their application in the enantioselective addition of dialkylzinc reagents to aldehydes and ketones

Doi:10.1016/S0957-4166(03)00045-4
(2003)
Reversible cross-linking and de-cross-linking system of polystyrenes bearing the monohydrate structure of vicinal tricarbonyl group through water-alcohol exchange reactions at ambient conditions

Doi:10.1021/ma301139v
(2012)

Article Doi