Synthesis of Pyridine Derivatives by Recations of α,β-Unsaturated Nitriles with 2-Oxo-cycloalkano Carbothioic Acid Anilides

DOI: 10.1007/BF00817308

Source and publish data:

Monatshefte fur Chemie p. 721 - 732 (1993)

Update date:2022-09-26

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Authors:

Bogdanowicz-Szwed, K.

Krasodomska, M.

Lipowska, M.

Rys, B. Rys, B.

Skonecka, A.

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Article abstract of DOI:10.1007/BF00817308

The tandem Michael addition-cyclization of 2-oxo-cycloalkane carbothioic acid anilides 1-3 to benzylidenemalononitrile 4 yielded spiroannulated pyridines 5-7.Reaction of acrylonitrile with 2 and 3 gave 2,2-disubstituted Michael adducts 14, 15, whereas with 1 led to 2,2,5-tri(2-cyanoethyl)cyclopentanone 11. - Keywords: 2-Oxo-cycloalkane carbothioic acid anilides; 3-Pyridine-spiro-2'-cycloalkanone; α,β-Unsaturated nitriles

Full text of DOI:10.1007/BF00817308

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