Synthesis of Pyridine Derivatives by Recations of α,β-Unsaturated Nitriles with 2-Oxo-cycloalkano Carbothioic Acid Anilides

DOI: 10.1007/BF00817308

Source and publish data:

Monatshefte fur Chemie p. 721 - 732 (1993)

Update date:2022-09-26

Topics:

Authors:

Bogdanowicz-Szwed, K.

Krasodomska, M.

Lipowska, M.

Rys, B. Rys, B.

Skonecka, A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1007/BF00817308

The tandem Michael addition-cyclization of 2-oxo-cycloalkane carbothioic acid anilides 1-3 to benzylidenemalononitrile 4 yielded spiroannulated pyridines 5-7.Reaction of acrylonitrile with 2 and 3 gave 2,2-disubstituted Michael adducts 14, 15, whereas with 1 led to 2,2,5-tri(2-cyanoethyl)cyclopentanone 11. - Keywords: 2-Oxo-cycloalkane carbothioic acid anilides; 3-Pyridine-spiro-2'-cycloalkanone; α,β-Unsaturated nitriles

Full text of DOI:10.1007/BF00817308

Products guided by the article

Product name:2,2,5-tri(2-cyanoethyl)-cyclopentanone

Cas No:13748-43-1

R&D Labs maybe for 13748-43-1

Chengdu King-tiger Pharm-chem. Tech. Co., Ltd

Contact:028-85317716

Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.
Chongqing Shuangfeng Chemical Co.,Ltd

Contact:+86-23-49850156

Address:No.663,xuanhua Rd,yongchuan,chongqing,China
Shanghai Run-Biotech Co., Ltd.

website:http://www.run-biotech.com

Contact:+86-21-31576854/57171705 / 57171706

Address:second floor, building 3, No.999, jiangyue Road, minghang District, Shanghai, China
SHANXI XINTIANYUAN PHARMACEUTICAL CO., LTD.

website:http://www.tychemical.com

Contact:0086-358-3521713 3521715

Address:No. 1 Yintong Road, Shanxi Jiaocheng Economic Development Zone, Xiajiaying Town, Jiaocheng County, Lvliang City, Shanxi Province, China
Hubei Xinghuo Chemical Co., Ltd.,

Contact:13925817279 13907299441

Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China

Relevant to this article

Antileishmanial activity of quinazoline derivatives: Synthesis, docking screens, molecular dynamic simulations and electrochemical studies

Doi:10.1016/j.ejmech.2014.12.051
(2015)
The direct α-C(sp³)-H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

Doi:10.1039/c4cc07913b
(2014)
Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

Doi:10.1016/j.bmcl.2014.04.012
(2014)
Air-stable, highly fluorescent primary phosphanes

Doi:10.1002/anie.201108416
(2012)
Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents

Doi:10.1021/jm990947f
(2000)
Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L.

Doi:10.1021/ja00029a028
(1992)

Article Doi