Simple Preparation of (2,2'-Biphenylylene)phenylphosphine Oxide and Role of Triphenylphosphine Oxide as a Mediator for Formation of Biaryl Derivatives

Article abstract of DOI:10.1246/bcsj.64.3182

(2,2'-Biphenylylene)phenylphosphine oxide (3) was prepared simply by the reaction of triphenylphosphine oxide (1) with phenyllithium and subsequently with aqueous hydrogen peroxide in acetic acid.The oxide 3 reacted with lithium diisopropylamide (LDA) and then with several elctrophiles to afford regiospecifically ortho-substituted compounds in moderate yields, which were converted to unsymmetrical 2- and 2,3'-substituted 1,1'-biaryls and triphenylphosphine oxide (1).