Acyloxymethyl as an activating group in lipase-catalyzed enantioselective hydrolysis. A versatile approach to chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates

DOI: 10.1016/S0040-4039(00)93560-3

Source and publish data:

Tetrahedron Letters p. 5805 - 5808 (1991)

Update date:2022-08-04

Topics:

Authors:

Ebiike Ebiike

Terao Terao

Achiwa Achiwa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)93560-3

The first practical syntheses of chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates, which are attractive compounds as new calcium antagonists, were realized by lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The monoesters obtained were revealed to have high optical purity and demonstrated to be useful chiral synthons.

Full text of DOI:10.1016/S0040-4039(00)93560-3

Products guided by the article

Product name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-phenyl-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester

Cas No:138279-23-9

R&D Labs maybe for 138279-23-9

Shanghai agrotree chemical co.,ltd.

Contact:+86-21-50117563

Address:Room 8A,liangfeng building,No.8 dongfang RD.pudong,shanghai,China
FREEBARQUE DEVELOPMENT GROUP LIMITED

Contact:+86(0)10-5109 5335 or 5109 5345

Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
suzhou chukai pharmateach co,.ltd

Contact:86-512-88812511

Address:Building 3, Wujiang Scientific Innovation Park, 2358 Changan Rd, Wujiang 215200, Jiangsu Province, P. R. China
Yurui(Shanghai)Chemical Co.,Ltd

Contact:0086 21-50456736

Address:No.3188 Xiupu Road,Shanghai
Shanghai TBBMed Co.,Ltd

website:http://www.tbbmed.com

Contact:86--21-50498136

Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China

Relevant to this article

SYNTHESIS AND ANALGESIC ACTIVITY OF SUBSTITUTED 1-ARYL-2-ACYLAMINOINDOLES

Doi:10.1007/BF00767254
(1991)
Design, synthesis and molecular modelling of novel 4-thiazolidinones of potential activity against Gram positive bacteria

Doi:10.1007/s00044-012-0115-x
(2013)
Multiple heating rate kinetic parameters, thermal, X-ray diffraction studies of newly synthesized octahedral copper complexes based on bromo-coumarins along with their antioxidant, anti-tubercular and antimicrobial activity evaluation

Doi:10.1016/j.saa.2012.05.057
(2012)
Electron-poor N-substituted imide-fused corannulenes

Doi:10.1039/c2cc32643d
(2012)
Microwave-Assisted Cascade Strategy for the Synthesis of Indolo[2,3-b]quinolines from 2-(Phenylethynyl)anilines and Aryl Isothiocynates

Doi:10.1021/acs.joc.6b02912
(2017)
Conformational analysis of 5-substituted 1,3-dioxanes. 5. Bond eclipsing in tert-butylsulfonyl-substituted 1,3-dioxanes and cyclohexanes. X-ray diffraction studies, MMP2 calculations, and interpretation

Doi:10.1021/ja00032a033
(1992)

Article Doi