Acyloxymethyl as an activating group in lipase-catalyzed enantioselective hydrolysis. A versatile approach to chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates

DOI: 10.1016/S0040-4039(00)93560-3

Source and publish data:

Tetrahedron Letters p. 5805 - 5808 (1991)

Update date:2022-08-04

Topics:

Authors:

Ebiike Ebiike

Terao Terao

Achiwa Achiwa

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Article abstract of DOI:10.1016/S0040-4039(00)93560-3

The first practical syntheses of chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates, which are attractive compounds as new calcium antagonists, were realized by lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The monoesters obtained were revealed to have high optical purity and demonstrated to be useful chiral synthons.

Full text of DOI:10.1016/S0040-4039(00)93560-3

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Product name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-phenyl-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester

Cas No:138279-23-9

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