
Journal of Organic Chemistry p. 1219 - 1223 (1992)
Update date:2022-08-04
Topics: Synthesis Stereoselective Chemical Reaction Experimental conditions 1,3-Amino Alcohols
Barluenga, Jose
Aguilar, Enrique
Fustero, Santos
Olano, Bernardo
Viado, Argimiro L.
syn,anti-N-Alkyl-1,3-amino alcohols 2 with three chiral centers are synthesized with high stereoselectivity by reduction of the corresponding anti-N-acylamino ketones 1 with LiAlH4/TiCl4.The intermediate N-acylamino alcohols 3 can be isolated when DIBALH/
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