Synthesis of (4S,5R)-(-)-4-Methyl-5-phenyloxazolidine-2-selone: A Chiral Auxiliary Reagent Capable of Detecting the Enantiomers of (R,S)-Lipoic Acid by 77Se Nuclear Magnetic Resonance Spectroscopy

Article abstract of DOI:10.1039/P19910002495

(4S,5R)-(-)-4-Methyl-5-phenyloxazolidine-2-selone was constructed in 5 steps on the 10-gram scale. 77Se NMR spectroscopic studies revealed that this selone served as a remarkably sensitive chiral auxiliary agent which readily distinguished the selone-coup