(1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide

Base Information

• Chemical Name: (1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide
• CAS No.: 138715-25-0
• Molecular Formula: C₁₆H₂₇NO₂Si
• Molecular Weight: 293.481
• Mol file: 138715-25-0.mol

Synonyms:(1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide

Chemical Property of (1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide

There total 3 articles about (1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (1R,2S)-(-)-2-Amino-1-phenyl-1-<(tert-butyldimethylsilyl)oxy>-propane (124368-83-8) → (1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide (138715-25-0)

Guidance literature:

In benzene; for 20h; Heating;

DOI:10.1039/P19910002495

Reference yield:

(1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) → (1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide (138715-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 95 percent / benzene / 20 h / Heating

With triethylamine; In dichloromethane; benzene;

DOI:10.1039/P19910002495

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (1S,2R)-N-<2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl>formamide (138715-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 95 percent / benzene / 20 h / Heating

With triethylamine; In dichloromethane; benzene;

DOI:10.1039/P19910002495

upstream raw materials:

formaldehyd

(1R,2S)-(-)-2-Amino-1-phenyl-1-<(tert-butyldimethylsilyl)oxy>-propane

(1R,2S)-norephedrine

tert-butyldimethylsilyl chloride

Downstream raw materials:

(1S,2R)-2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl isocyanide

(1S,2R)-2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl isoselenocyanate

(4S,5R)-3-<5-(1,2-dithiolan-3-yl)-1-oxopentyl>-4-methyl-5-phenyloxazolidine-2-selone

(4S,5R)-(-)-4-Methyl-5-phenyloxazolidine-2-selone