Synthesis of novel cephem-4-ketones. A new series of human leukocyte elastase inhibitors

DOI: 10.1016/0040-4039(91)80790-D

Source and publish data:

Tetrahedron Letters p. 6207 - 6210 (1991)

Update date:2022-09-26

Topics:

Authors:

Alpegiani, Marco

Bissolino, Pierluigi

Perrone, Ettore

Cassinelli, Giuseppe

Franceschi, Giovanni

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Article abstract of DOI:10.1016/0040-4039(91)80790-D

Alkylation of cephem-4-carbonyl chlorides at the sulphide or sulphone oxidation level with Grignard reagents, stannanes and cuprates is described. Radical or ionic bromination of the 3-methylcephem-4-ketone 8, followed by displacement with heterocyclic th

Full text of DOI:10.1016/0040-4039(91)80790-D

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