Synthesis of novel cephem-4-ketones. A new series of human leukocyte elastase inhibitors

Article abstract of DOI:10.1016/0040-4039(91)80790-D

Alkylation of cephem-4-carbonyl chlorides at the sulphide or sulphone oxidation level with Grignard reagents, stannanes and cuprates is described. Radical or ionic bromination of the 3-methylcephem-4-ketone 8, followed by displacement with heterocyclic th