Synthesis of novel cephem-4-ketones. A new series of human leukocyte elastase inhibitors

DOI: 10.1016/0040-4039(91)80790-D

Source and publish data:

Tetrahedron Letters p. 6207 - 6210 (1991)

Update date:2022-09-26

Topics:

Authors:

Alpegiani, Marco

Bissolino, Pierluigi

Perrone, Ettore

Cassinelli, Giuseppe

Franceschi, Giovanni

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(91)80790-D

Alkylation of cephem-4-carbonyl chlorides at the sulphide or sulphone oxidation level with Grignard reagents, stannanes and cuprates is described. Radical or ionic bromination of the 3-methylcephem-4-ketone 8, followed by displacement with heterocyclic th

Full text of DOI:10.1016/0040-4039(91)80790-D

Products guided by the article

Product name:3-<<<6-(benzhydryloxy)-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl>thio>methyl>-4-(tert-butylcarbonyl)-7α-methoxy-Δ³-cephem 1,1-dioxide

Cas No:138736-57-9

R&D Labs maybe for 138736-57-9

Zhejiang Allied Chemical Co.,Ltd

Contact:18967038207

Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Hebei Lead Bio-Chemicals Co., Ltd.

website:http://www.ldbiochem.com

Contact:+86-311-87826503

Address:481, Heping West Road, Shijiazhuang,China
Shanghai Micro-mega Industry Co., Ltd.

Contact:0086-21-34628682;57153848

Address:Rm413,No.413,West Meilong Road, Minhang District,Shanghai P R China
Huangshan Violet Biological Technology Co., Ltd

Contact:+86-559-2335676

Address:16-201 JinShanYuan,JiangNan New City,TunXi District,HuangShan City,AnHui Province,China
Suqian Ruixing Chemical Co., Ltd.

Contact:+86-527-80805666（总机）;84836008(销售)

Address:3 Jingsilu, Zone north, Hubin Xincheng Development Park, Suqian, China

Relevant to this article

Diastereo- and enantioselective allylic S(N') substitution by phenylacetic esters enolates

Doi:10.1016/S0957-4166(00)82008-X
(1991)
A Facile Sythesis of 1,2,3,4-Tetrahydroisoquinolines Through Cyclization of O,N-Acetals

Doi:10.1055/s-1987-28089
(1987)
Cu(i)/{Nb₆O₁₉} catalyzed: N -acylation of arylacetic acids with amines under aerobic conditions

Doi:10.1039/c8cc06721j
(2018)
A fluorene-modified porphyrin for efficient dye-sensitized solar cells

Doi:10.1039/c2cc30892d
(2012)
On the stereochemical divergence in the conjugate addition of lithium dimethylcuprate/trimethylsilyl chloride to γ-alkoxy and γ-ureido α,β-unsaturated esters

Doi:10.1055/s-1991-28396
(1991)
Rh-catalyzed borylation of N-adjacent C(sp³)-H bonds with a silica-supported triarylphosphine ligand

Doi:10.1021/ja305694r
(2012)

Article Doi