LDA-catalyzed diastereoselective Michael-additions with glycine derivatives: Synthesis of 4-substituted 3-aryl-N(diphenylmethylene)glutamates followed by cyclization to 4-substituted 3-aryl-2-ethoxycarbonyl-5-oxo-pyrrolidines

DOI: 10.1002/ardp.2503241210

Source and publish data:

Archiv der Pharmazie p. 989 - 995 (1991)

Update date:2022-08-04

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Authors:

Pachaly Pachaly

Kang Kang

Wahl Wahl

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Article abstract of DOI:10.1002/ardp.2503241210

Synthesis and stereochemistry of 4-substituted diethyl 3-aryl-N(diphenylmethylene)glutamate 3 by LDA-catalyzed Michael addition of ethyl-N(diphenylmethylene)glycinate with diethylbenzylidene-malonate or ethyl-2-cyanocinnamates, respectively. are reported.

Full text of DOI:10.1002/ardp.2503241210

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