LDA-catalyzed diastereoselective Michael-additions with glycine derivatives: Synthesis of 4-substituted 3-aryl-N(diphenylmethylene)glutamates followed by cyclization to 4-substituted 3-aryl-2-ethoxycarbonyl-5-oxo-pyrrolidines

Article abstract of DOI:10.1002/ardp.2503241210

Synthesis and stereochemistry of 4-substituted diethyl 3-aryl-N(diphenylmethylene)glutamate 3 by LDA-catalyzed Michael addition of ethyl-N(diphenylmethylene)glycinate with diethylbenzylidene-malonate or ethyl-2-cyanocinnamates, respectively. are reported.