Syntheses and Thymidylate Synthase Inhibitory Activity of the Poly-γ-glutamyl Conjugates of N--2-thenoyl>-L-glutamic Acid (ICI D1694) and Other Quinazoline Antifolates

DOI: 10.1021/jm00083a008

Source and publish data:

Journal of Medicinal Chemistry p. 859 - 866 (1992)

Update date:2022-08-04

Topics:

Authors:

Bisset, Graham M. F.

Pawelczak, Krzysztof

Jackman, Ann L.

Calvert, A. Hilary

Hughes, Leslie R.

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Article abstract of DOI:10.1021/jm00083a008

Thirteen poly-γ-glutamates derived from several novel antifolates have been synthesized by a convergent route.The syntheses of poly-γ-glutamyl conjugates of N-<5--2-thenoyl>-L-glutamic aci

Full text of DOI:10.1021/jm00083a008

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