Syntheses and Thymidylate Synthase Inhibitory Activity of the Poly-γ-glutamyl Conjugates of N--2-thenoyl>-L-glutamic Acid (ICI D1694) and Other Quinazoline Antifolates

DOI: 10.1021/jm00083a008

Source and publish data:

Journal of Medicinal Chemistry p. 859 - 866 (1992)

Update date:2022-08-04

Topics:

Authors:

Bisset, Graham M. F.

Pawelczak, Krzysztof

Jackman, Ann L.

Calvert, A. Hilary

Hughes, Leslie R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00083a008

Thirteen poly-γ-glutamates derived from several novel antifolates have been synthesized by a convergent route.The syntheses of poly-γ-glutamyl conjugates of N-<5--2-thenoyl>-L-glutamic aci

Full text of DOI:10.1021/jm00083a008

Products guided by the article

Product name:Benzoic acid, 4-[[(4-chloro-2-methyl-6-quinolinyl)methyl]-2-propynylamino]-2-fluoro-

Cas No:138899-81-7

R&D Labs maybe for 138899-81-7

lianyungang jinkang pharmaceutical technology co., ltd.

Contact:008651885445517

Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
Borun Chemical Co.,Ltd.

Contact:+86-574- 87178138; 87297407

Address:No. 809, Liudingxingzuo, cangsong road, Ningbo, China
Luzhou North Chemical Co., Ltd.

Contact:+86-830-2796784；+86-830-2796776

Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
Qingdao Kylin Trading Co., Ltd.

Contact:0086-532-68979884/58972912/68972263/65/88171519

Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Hubei Xiangxi Chemical Industry Co.,Ltd

Contact:+86-710-3454830

Address:No.7, Daqing East Road, Xiangfan City, Hubei Province, China

Relevant to this article

Tritiated chiral alkanes as substrates for soluble methane monooxygenase from Methylococcus capsulatus (Bath): Probes for the mechanism of hydroxylation

Doi:10.1021/ja963971g
(1997)
Palladium(II)-Catalyzed Direct Access to Indeno[1,2-c]isochromen-5(11H)-Ones via Intramolecular Oxypalladation-Initiated Cascade Process

Doi:10.1002/adsc.202000456
(2020)
Additive Pummerer reactions of vinylic sulphoxides. Synthesis of 2-(phenylsulphenyl) aldehydes and primary alcohols

Doi:10.1016/0040-4039(91)80458-I
(1991)
Novel classes of alkynyliodonium salts and their applications: The synthesis of substituted 1,3-diynyliodonium triflates, R-C≡C-C≡C-I⁺-Ph ^-OTf, and their reaction with triphenylphosphine

Doi:10.1055/s-1991-26681
(1991)
Anthranilamide (aam)-substituted arylboranes in direct carbon-carbon bond-forming reactions

Doi:10.1039/c8cc10252j
(2019)
N-isocyaniminotriphenylphosphorane as an efficient reagent for the synthesis of disubstituted 1,3,4-oxadiazoles via in-situ generation of sterically congested iminophosphorane derivatives

Doi:10.1080/10426507.2012.668983
(2012)

Article Doi