Intramolecular trapping of difluoroalkyl radicals by tethered olefin in the asymmetric synthesis of 2,4-disubstituted-3,3-difluorotetrahydrofurans

Article abstract of DOI:10.1016/S0040-4020(01)80890-5

Optically pure propenyl ethers of 3-sulphenyl-, 3-sulphuryl-, and 3-sulphonyl-1-chloro-1,1-difluoropropan-2-ols were submitted to radical cyclization affording, with moderate to high diastereoselectivity. 3,3-difluorotetrahydrofurans containing in 2 and 4