Aryloxyacetic acid diuretics with uricosuric activity. II. Substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids and the related compounds

DOI: 10.1248/cpb.39.2681

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2681 - 2690 (1991)

Update date:2022-08-04

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Authors:

Kitagawa

Yamamoto

Katakura

Kanno Kanno

Yamada Yamada

Nagahara

Tanaka Tanaka

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Article abstract of DOI:10.1248/cpb.39.2681

Di- and tri-substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids, and 4-oxo-3-phenyl-4H-furo[2,3-h][1]benzopyran-8-carboxylic acid were synthesized and tested for natriuretic and uricosuric activities. Among the compounds tested, 3,5-disubstituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids (6c-f, h, n and x) showed potent natriuretic and uricosuric activities, whereas 4-oxo-3-phenyl-4H-furo[2,3-h][1]benzopyran-8-carboxylic acid (6dd) possessed only potent natriuretic activity. The structure-activity relationships are also discussed.

Full text of DOI:10.1248/cpb.39.2681

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