Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors

DOI: 10.1016/j.bmcl.2012.05.125

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4528 - 4531 (2012)

Update date:2022-09-26

Topics:

Authors:

Ji, Zhiqin

Dai, Yujia

Abad-Zapatero, Cele

Albert, Daniel H.

Bouska, Jennifer J.

Glaser, Keith B.

Marcotte, Patrick A.

Soni, Nirupama B.

Magoc, Terry J.

Stewart, Kent D.

Wei, Ru-Qi

Davidsen, Steve K.

Michaelides, Michael R.

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Article abstract of DOI:10.1016/j.bmcl.2012.05.125

Four hinge-binding scaffolds have been explored for novel selective Aurora kinase inhibitors. The structure activity relationship, selectivity and pharmacokinetic profiles have been evaluated.

Full text of DOI:10.1016/j.bmcl.2012.05.125

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