Directed metallation studies on 2-(2-heteroaryl)imidazolines: Synthesis of some 2,3-disubstituted thiophenes and furans

Article abstract of DOI:10.1016/S0040-4020(01)80726-2

A general method for the synthesis of 2-(2-heteroaryl)imidazolines (1a-c) has been developed and subsequent metallation studies have shown the imidazole group to be a strong director of ortho-metallation. The synthetic utility of lithio intermediates (5) and (7) has been shown by reaction with a series of electrophiles.