European Journal of Medicinal Chemistry p. 147 - 155 (1995)
Update date:2022-08-04
Topics:
Michon
Herve du Penhoat
Tombret
Gillardin
Lepage
Berthon
Some unsymmetrical N-exocyclic and N-endocyclic derivatives from benzoylation of 3- and 5-aminopyrazole were prepared with the aim of comparing their anticonvulsant activity towards the MES and scMET tests. Unambiguous proof of their structure was obtained from heteronuclear long-range correlation spectroscopy and NOE difference spectra. Only the N-exo-pyrazole benzamides showed good protection with respect to these tests.
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