Preparation, structural analysis and anticonvulsant activity of 3- and 5-aminopyrazole N-benzoyl derivatives

DOI: 10.1016/0223-5234(96)88220-1

Source and publish data:

European Journal of Medicinal Chemistry p. 147 - 155 (1995)

Update date:2022-08-04

Topics:

Authors:

Michon Michon

Herve du Penhoat

Tombret Tombret

Gillardin

Lepage Lepage

Berthon Berthon

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Article abstract of DOI:10.1016/0223-5234(96)88220-1

Some unsymmetrical N-exocyclic and N-endocyclic derivatives from benzoylation of 3- and 5-aminopyrazole were prepared with the aim of comparing their anticonvulsant activity towards the MES and scMET tests. Unambiguous proof of their structure was obtained from heteronuclear long-range correlation spectroscopy and NOE difference spectra. Only the N-exo-pyrazole benzamides showed good protection with respect to these tests.

Full text of DOI:10.1016/0223-5234(96)88220-1

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