Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: Synthesis and in vitro biological evaluation

DOI: 10.1021/jm00087a012

Source and publish data:

Journal of Medicinal Chemistry p. 1578 - 1588 (1992)

Update date:2022-09-26

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Authors:

Rosowsky

Forsch Forsch

Reich Reich

Freisheim

Moran Moran

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Article abstract of DOI:10.1021/jm00087a012

5-Deazafolate and 5-deazatetrahydrofolate (DATHF) analogues with the glutamic acid side chain replaced by homocysteic acid (HCysA), 2-amino-4- phosphonobutanoic acid (APBA), and ornithine (Orn) were synthesized as part of a larger program directed toward

Full text of DOI:10.1021/jm00087a012

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