Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: Synthesis and in vitro biological evaluation

DOI: 10.1021/jm00087a012

Source and publish data:

Journal of Medicinal Chemistry p. 1578 - 1588 (1992)

Update date:2022-09-26

Topics:

Authors:

Rosowsky

Forsch Forsch

Reich Reich

Freisheim

Moran Moran

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00087a012

5-Deazafolate and 5-deazatetrahydrofolate (DATHF) analogues with the glutamic acid side chain replaced by homocysteic acid (HCysA), 2-amino-4- phosphonobutanoic acid (APBA), and ornithine (Orn) were synthesized as part of a larger program directed toward

Full text of DOI:10.1021/jm00087a012

Products guided by the article

Product name:D.L-2-<(nitrobenzoyl)amino>-4-phosphonobutanoic acid

Cas No:139347-37-8

R&D Labs maybe for 139347-37-8

ClickChem Technology Co., Limited

Contact:+86-0310-6519966/0531-52893837

Address:No.750 Shunhua Road, High-Tech Zone, Jinan city, Shandong China
A-Chem Technologies Co.,Ltd.

Contact:+86-512-69561895

Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
SuZhou Yacoo Science Co., Ltd

Contact:86-512-87182055

Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
MINS GROUP CO.,LIMITED

Contact:18669908765

Address:Zibo City, Shandong Province, P.R.China
Shanghai Gsyn Chemical Co.,Ltd.

Contact:86-021-67158290

Address:86-021-67158291

Relevant to this article

Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents

Doi:10.1016/j.ejmech.2015.04.028
(2015)
Chiral acetylenic sulfoxide in alkaloid synthesis. Total synthesis of (R)-(+)-carnegine

Doi:10.1016/0040-4039(91)80426-7
(1991)
Synthesis of ligands related to the O-specific antigen of type 1 Shigella dysenteriae. 3. Glycosylation of 4,6-O-substituted derivatives of methyl 2-acetamido-2-deoxy-α-D-glucopyranoside with glycosyl donors derived from mono- and oligosaccharides

Doi:10.1021/jo00034a047
(1992)
Palladium-catalyzed C-H cyclization in water: A milder route to 2-arylbenzothiazoles

Doi:10.1055/s-0031-1291164
(2012)
Thermal and light control of the sol-gel phase transition in cholesterol-based organic gels. Novel helical aggregation modes As detected by circular dichroism and electron microscopic observation

Doi:10.1021/ja00094a023
(1994)
Highly Enantioselective Synthesis of a Corey Prostaglandin Intermediate

Doi:10.1016/S0957-4166(00)82318-6
(1992)

Article Doi