
Tetrahedron Letters p. 8315 - 8318 (1997)
Update date:2022-08-05
Topics: Experimental conditions Mediated
Kita, Yasuyuki
Yoshida, Yutaka
Mihara, Sachiko
Fang, Dai-Fei
Higuchi, Kazuhiro
Furukawa, Akihiro
Fujioka, Hiromichi
An efficient pinacol rearrangment mediated by trimethyl orthoformate has been developed. The reactions of various types of diols with catalytic amount of a Lewis acid in the presence of an ortho eater afforded the rearranged product in good yields via a cyclic ortho ester intermediate.
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