Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation

DOI: 10.1021/jm00085a013

Source and publish data:

Journal of Medicinal Chemistry p. 1259 - 1266 (1992)

Update date:2022-08-04

Topics:

Authors:

Fournie-Zaluski

Coric Coric

Turcaud Turcaud

Bruetschy

Lucas Lucas

Noble Noble

Roques Roques

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Article abstract of DOI:10.1021/jm00085a013

Derivatives of amino acids bearing various zinc-coordinating moieties (SH, COOH, CONHOH, and PO₃H₂) were synthesized and tested for their ability to inhibit aminopeptidase N (APN). Among them, β-amino thiols were found to be the most

Full text of DOI:10.1021/jm00085a013

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