Stereocontrolled Total Synthesis of the Unnatural Enantiomers of Castanospermine and 1-epi-Castanospermine

DOI: 10.1021/jo00037a043

Source and publish data:

Journal of Organic Chemistry p. 3194 - 3202 (1992)

Update date:2022-08-04

Topics:

Authors:

Mulzer, Johann

Dehmlow, Henrietta

Buschmann, Juergen

Luger, Peter

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Article abstract of DOI:10.1021/jo00037a043

A concise practical synthesis (13 steps, ca. 10-12percent overall yield) of the unnatural enantiomer of castanospermine ((-)-1) and its 1-epimer 2 from 2,3,4-tri-O-benzyl-D-xylose (3) is described.Key steps in the synthesis are two organometal aldehyde ad

Full text of DOI:10.1021/jo00037a043

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