Synthesis of N-methyl-2-indolyl- and N-methyl-2-benzo[b]furyl-substituted sulfoximines by Pd/Cu co-catalyzed domino cross-coupling/cyclization reactions

Article abstract of DOI:10.1002/ejoc.201200573

Domino cross-coupling/cyclization reactions of N-propargyl sulfoximines and 2-iodophenols or 2-iodoanilides are catalyzed by a cooperative palladium/copper system to provide benzo[b]furan and indole derivatives in good to excellent yields. The reactions occur under mild conditions and tolerate a wide variety of functional groups. Domino cross-coupling/cyclization reactions of N-propargyl sulfoximines and 2-iodophenols or 2-iodoanilides are catalyzed by a cooperative palladium/copper system to provide benzo[b]furan and indole derivatives in good to excellent yields. The reactions occur under mild conditions and tolerate a wide variety of functional groups. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.