SYNTHESIS AND STRUCTURE OF 5-METHYL-1-(2-R-PHENYL)DIHYDRO-2,4-(1H,3H)-PYRIMIDINEDIONES AND THEIR 2-THIONO ANALOGS

Article abstract of DOI:10.1007/BF00484366

The reaction of o-substituted aromatic amines with methacrylic acid gave N-aryl-α-methyl-β-alanines, which were converted to dihydro-2,4-pyrimidinedione and dihydro-4-pyrimidinone-2-thione derivatives.The alkylation, acylation, and oximation of the dihydr