XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids

DOI: 10.1021/ol400045d

Source and publish data:

Organic Letters p. 902 - 905 (2013)

Update date:2022-08-05

Topics:

Authors:

Orliac, Aurélie

Gomez Pardo, Domingo

Bombrun, Agnès

Cossy, Janine

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Article abstract of DOI:10.1021/ol400045d

Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.

Full text of DOI:10.1021/ol400045d

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