A General Approach to the Asymmetric Synthesis of Vancomycin-Related Arylglycines by Enolate Azidation

DOI: 10.1016/S0040-4039(00)91892-6

Source and publish data:

Tetrahedron Letters p. 1189 - 1192 (1992)

Update date:2022-08-02

Topics: Asymmetric synthesis Diastereoselectivity Column chromatography Yield NMR spectroscopy Enantiomeric excess (ee) Recrystallization Catalytic hydrogenation HPLC (high-performance liquid chromatography) Protecting group Azidation Chiral Auxiliary Reaction Optimization Enolate Vancomycin

Authors:

Evans, David A.

Evrard, Deborah A.

Rychnovsky, Scott D.

Frueh, Thomas

Whittingham, William G.

DeVries, Keith M.

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Article abstract of DOI:10.1016/S0040-4039(00)91892-6

The asymmetric synthesis of vancomycin-related α-azido arylglycines by direct azide transfer methodology is reported.Procedures for the conversion of the azides to N-protected arylglycines are provided.

Full text of DOI:10.1016/S0040-4039(00)91892-6

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