Propargyl and Allyl Grignard and Zinc Reagents. Regioselective Alkylation and Its Application to the Synthesis of PGE3 and F3α Methyl Ester

DOI: 10.1021/jo00283a004

Source and publish data:

Journal of Organic Chemistry p. 5198 - 5200 (1989)

Update date:2022-08-05

Topics:

Authors:

Yanagisawa, Akira

Habaue, Shigeki

Yamamoto, Hisashi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00283a004

Regioselective propargylation and allylation were achieved using acylsilanes as electrophiles, and this methodology was applied to the synthesis of PGE₃ and F_3α methyl ester.

Full text of DOI:10.1021/jo00283a004

Products guided by the article

Product name:2,2-Dimethyl-1-phenyl-1-triisopropylsilanyl-but-3-en-1-ol

Cas No:141423-46-3

R&D Labs maybe for 141423-46-3

Nanjing Zelang Medical Technology Co. Ltd

Contact:86-25-83063290/13770714480

Address:Ganjiabian 108# 01 Unit,701-702 room,Yao Hua Street,Qixia District,Nanjing,Jiangsu,China
Jintan City Mego Chemical Co., Ltd

Contact:+86-0519-82814387

Address:23# Dengguan Town, Jintan, Jiangsu Province, China
Beyond Pharmaceutical Co., Ltd

Contact:+86-571-8195-3185

Address:No. 13-1, Liansheng Road, Yuhang District
Jiangxi Hito Chemical Co., Ltd.

Contact:+86-792-3170318

Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China
Ji'nan Orgachem Pharmaceutical Co.,Ltd

Contact:+86-531-82687810

Address:Jinan

Relevant to this article

An oxidopyrylium cyclization/ring-opening route to polysubstituted α-hydroxytropolones

Doi:10.1021/ol302892g
(2012)
Functionalized carbodiimide mediated synthesis of 2,3-disubstituted quinazolin-4(3 H)-ones via the tandem strategy of C-nucleophilic addition and intramolecular NH-substitution cyclization

Doi:10.1055/s-0032-1316773
(2012)
Enantioselective construction of multifunctionalized spirocyclohexaneoxindoles through organocatalytic Michael-Aldol cyclization of isatin derived alkenes with linear dialdehydes

Doi:10.1039/c2ob26205c
(2012)
Palladium-Catalyzed Asymmetric Arylation of Trifluoromethylated/Perfluoroalkylated 2-Quinazolinones with High Enantioselectivity

Doi:10.1002/chem.201603105
(2016)
Benzylidene succinimides as 3C synthons for the asymmetric tandem Mannich reaction/transamidation of cyclic trifluoromethyl ketimines to obtain F₃C-containing polycyclic dihydroquinazolinones

Doi:10.1039/d0cc08131k
(2021)
Evaluation of a ¹²⁵I-labelled benzazepinone derived voltage-gated sodium channel blocker for imaging with SPECT

Doi:10.1039/c2ob26695d
(2012)

Article Doi