Stereospecific Synthesis of the Top-Half Precursor to the Antitumor Agent Vinblastine and a Simple Bisindole Analogue.

DOI: 10.1016/S0040-4039(00)91570-3

Source and publish data:

Tetrahedron Letters p. 899 - 902 (1992)

Update date:2022-07-30

Topics: Oxidation Asymmetric synthesis Yield NMR spectroscopy Mass spectrometry Solvent Reduction Enantiomeric excess (ee) Chromatography Precursor Alkaloid Protecting group Retrosynthetic analysis Catalysis Coupling Reaction Indole Reaction Optimization Stereospecific synthesis Vinblastine

Authors:

Magnus, Philip

Mendoza, Jose

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Article abstract of DOI:10.1016/S0040-4039(00)91570-3

The stereospecific synthesis of a precursor to the top-half of vinblastine is described.Its non-oxidative coupling to m-methoxy-N,N-dimethylaniline provides access to the vinblastine analogue 18.

Full text of DOI:10.1016/S0040-4039(00)91570-3

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