Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives

DOI: 10.1021/jm00092a016

Source and publish data:

Journal of Medicinal Chemistry p. 2652 - 2658 (1992)

Update date:2022-07-29

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Authors:

Cunliffe

Franklin

Hales Hales

Hill Hill

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Article abstract of DOI:10.1021/jm00092a016

N-Oxaloglycine (3) is an α-ketoglutarate (1) analogue that is a competitive inhibitor of prolyl 4-hydroxylase (EC 1.14.11.2). A study of the structure-activity relationships of some other oxalo derivatives shows that substitution on the glycine moiety mod

Full text of DOI:10.1021/jm00092a016

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