Bioorganic and Medicinal Chemistry Letters p. 407 - 411 (2013)
Update date:2022-07-29
Topics:
Gillman, Kevin W.
Parker, Michael F.
Silva, Mark
Degnan, Andrew P.
Tora, George O.
Lodge, Nicholas J.
Li, Yu-Wen
Lelas, Snjezana
Taber, Matthew
Krause, Rudolf G.
Bertekap, Robert L.
Newton, Amy E.
Pieschl, Rick L.
Lengyel, Kelly D.
Johnson, Kim A.
Taylor, Sarah J.
Bronson, Joanne J.
MacOr, John E.
A series of substituted pyridines, ether linked to a phenylpiperidine core were optimized for dual NK1/SERT affinity. Optimization based on NK1/SERT binding affinities, and minimization of off-target ion channel activity lead to the
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Doi:10.1002/ejoc.201200759
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