Recyclable and reusable chiral α, α-L-diaryl prolinol heterogeneous catalyst grafting to UiO-67 for enantioselective hydration/aldol/oxa-Diels Alder domino reaction

Article abstract of DOI:10.1016/j.catcom.2020.106249

α,α-L-Diaryl prolinol was first introduced into a highly stable porous MOF, UiO-67, via the immobilization of a chiral prolinol side chain into 4,4′-biphenyldicarboxylic acid through a five-step process, to construct a chiral heterogeneous catalyst. The catalyst exhibited high yield (up to 88%) and excellent stereoselectivities (up to >4:1 dr, > 80% ee) for the enantioselective hydration/aldol/oxa-Diels Alder domino reactions, as well as good reusability with recycle use for three times without significant loss of activity. To our knowledge, this is the first report of chiral MOFs as heterogeneous catalysts for asymmetric domino reactions.

Full text of DOI:10.1016/j.catcom.2020.106249

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JACC March 21, 2017
Volume 69, Issue 11
FIT Clinical Decision Making
VENTRICULAR PAPILLARY FIBROELASTOMA PRESENTING AS PERIPHERAL ARTERY DISEASE
Poster Contributions
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: FIT Clinical Decision‐Making: Interventional Cardiology, Acute and Stable Ischemic Heart Disease, and Vascular Medicine
Abstract Category: Vascular Medicine
Presentation Number: 1300-394
Authors: Julio Perez-Downes, Harold Dietzius, Vasant Jayasankar, Leslie Oberst, University of Florida College of Medicine- Jacksonville,
Jacksonville, FL, USA, Memorial Hospital of Jacksonville, Jacksonville, FL, USA
Background: Cardiac tumors are an exceedingly rare phenomena. Papillary fibroelastomas are the second most common benign cardiac
tumors. Despite their propensity to cause embolic strokes and acute coronary syndrome, a major consideration is also that of symptomatic
peripheral artery disease as a presentation.
Case: A 77 year-old female with history of a prior transient ischemic attack and hypertension presented to the hospital with severe pain
within her right great toe after undergoing partial amputation a couple of weeks prior. On physical exam, she was found to have absent
pulses within the popliteal and right femoral arteries. In anticipation for further surgical intervention, pre-operative cardiac evaluation was
performed with a transthoracic echocardiogram that showed an ejection fraction of 75%, no regional wall motion abnormalities, and a well
defined, mobile mass within the left ventricle measuring 18x14mm.
Decision-Making: Further cardiovascular evaluation was obtained, with transesophageal echocardiogram confirming the finding of a
18x12mm pedunculated mass attached to the septal wall of the left ventricle. Right lower extremity angiography revealed total occlusion
of the proximal segments of the right anterior tibial and peroneal arteries, as well as a total occlusion within the distal segment of the
posterior tibial artery. Due to the finding of a cardiac mass causing peripheral embolization, the decision for surgical resection was reached.
Pathological examination confirmed the diagnosis of papillary fibroelastoma of the left ventricle. The patient tolerated the procedure well
and made a successful recovery.
Conclusions: This case highlights the importance of a complete cardiac evaluation for patients presenting with peripheral vascular disease
without known risk factors. Furthermore, it reinforces the importance of the echocardiogram to identify or exclude cardiac tumors as a
potential cause of peripheral embolic phenomena