INVESTIGATIONS OF 2-SUBSTITUTED IMIDAZOLES. 2. SYNTHESIS AND ELECTROPHILIC SUBSTITUTION OF 1-METHYL-2-(THIENYL-2)IMIDAZOLE. A CONVENIENT METHOD OF METHYLATION OF 2-R-IMIDAZOLES

Article abstract of DOI:10.1007/BF00486814

We have synthesized 2-(thienyl-2)imidazole and its N-methyl derivative.The latter product was obtained by nitration, bromination, acylation, and formylation, occurring as a rule on the thiophene ring.A general method for methylating 2-R-imidazoles with methyl iodide KOH-dimethoxy ethane is proposed.